Job Bank UCMC News Calendar Community Links Community Education Gaffney Community 1530 N. Limestone Street Gaffney, SC 29340 864.487.4271 mail@upstatecarolina.org		Gaffney, South Carolina, is proud of the fine health care available at Upstate Carolina Medical Center. Gaffney is located in Cherokee County, in the Upstate region of South Carolina. Over the last ten years, Cherokee County has grown dramatically, with new businesses and industries choosing to locate in this conveniently situated community halfway between Greenville, South Carolina, and Charlotte, North Carolina on I-85. Spartanburg, South Carolina, is only a short drive, too. The county boasts a thriving educational system, with a newly constructed Gaffney High School and many recently constructed elementary schools. Limestone College, a private liberal arts college founded in 1845, also calls Gaffney home.